The synthetic toxin 2,4-dinitrophenol can uncouple ATP synthesis from mitochondrial respiration by decreasing the permeability of the inner membrane to protons. What would be the effect of dinitrophenol treatment on the amount of ATP produced by mitochondria and on the rate of ATP transport across the inner membrane, respectively?

Question

Quizplus · Accepted Answer

By diminishing the electrochemical gradient across the inner membrane, the toxin interferes with ATP synthesis and ATP/ADP exchange, both of which are driven by the gradient.

The Synthetic Toxin 2,4-Dinitrophenol Can Uncouple ATP Synthesis from Mitochondrial