The Src kinase can be regulated by at least two mechanisms. Kinases of the CSK family inactivate Src by phosphorylating a C-terminal tyrosine residue. On the other hand, binding of activating ligands (including some activated receptor tyrosine kinases, or RTKs) results in autophosphorylation at a tyrosine residue near the active site, stimulating Src activity. Full activation of Src therefore requires both dephosphorylation at the inhibitory tyrosine and binding to an RTK. Which of the following logic gates (A to E) correctly models the activation of Src kinase (output) as a function of the activity of the upstream regulators (inputs)?

Question

Quizplus · Accepted Answer

The activation of Src can be described as "(RTK) AND NOT (CSK)."

The Src Kinase Can Be Regulated by at Least Two