What is the major way by which the monomeric G protein Ras is activated in receptor tyrosine kinase signaling?

Question

Quizplus · Accepted Answer

Ras is activated by guanine nucleotide exchange (GDP release and GTP binding), which is catalyzed by upstream Ras guanine nucleotide exchange factors (Ras-GEFs). In contrast, Ras GTPase-activating proteins (Ras-GAPs) increase the rate of GTP hydrolysis by Ras and therefore inactivate it. Guanine nucleotide dissociation inhibitors (GDIs) prevent the association of some GTPases with their GEFs, thereby keeping the GTPases inactive.

What Is the Major Way by Which the Monomeric G