Indicate whether each of the following occurs inside the cell in the presence (P) or absence (A) of stimulation with a Hedgehog signal. Your answer would be a four-letter string composed of letters P and A only, e.g. PPPP.
( ) Sequestration of Smoothened in intracellular vesicles
( ) Accumulation of unprocessed Ci in the nucleus
( ) Phosphorylation of Smoothened
( ) Recruitment of Fused and Costal2 to the plasma membrane

Question

Indicate whether each of the following occurs inside the cell in the presence (P) or absence (A) of stimulation with a Hedgehog signal. Your answer would be a four-letter string composed of letters P and A only, e.g. PPPP.
( )	Sequestration of Smoothened in intracellular vesicles
( )	Accumulation of unprocessed Ci in the nucleus
( )	Phosphorylation of Smoothened
( )	Recruitment of Fused and Costal2 to the plasma membrane

Quizplus · Accepted Answer

In the presence of the Hedgehog signal, Smoothened is phosphorylated and recruited to the plasma membrane, where it recruits the complex containing Ci, Fused, and Costal and inhibits Ci proteolysis. This results in the accumulation of unprocessed Ci in the nucleus and transcriptional activation of target genes.

Indicate Whether Each of the Following Occurs Inside the Cell