Indicate true (T) and false (F) statements below regarding apoptosis in disease. Your answer would be a four-letter string composed of letters T and F only, e.g. TTTF.
( ) Either excessive or insufficient apoptosis can contribute to disease.
( ) Excessive apoptosis, in many cases, leads to autoimmune disease and cancer.
( ) In about half of human cancers, the tumor suppressor protein p53 is mutated.
( ) Drugs that interfere with the function of Bcl2 family proteins such as Bax and Bak may treat cancers by stimulating apoptosis.

Question

Indicate true (T) and false (F) statements below regarding apoptosis in disease. Your answer would be a four-letter string composed of letters T and F only, e.g. TTTF.
( )	Either excessive or insufficient apoptosis can contribute to disease.
( )	Excessive apoptosis, in many cases, leads to autoimmune disease and cancer.
( )	In about half of human cancers, the tumor suppressor protein p53 is mutated.
( )	Drugs that interfere with the function of Bcl2 family proteins such as Bax and Bak may treat cancers by stimulating apoptosis.

Quizplus · Accepted Answer

Contribution to disease can come from either excessive apoptosis (e.g. in strokes) or insufficient apoptosis (e.g. in some autoimmune disease and cancers). The p53 protein normally arrests the cell cycle or initiates apoptosis in response to DNA damage, which explains why the loss of p53 function is of benefit to, and is widely observed in, cancer cells.

Indicate True (T) and False (F) Statements Below Regarding Apoptosis