The requirement for accumulation of multiple mutations in cancer progression is manifested in the normalized percentage of new cases of cancer diagnosed in different age groups. Which of the curves A to E in the following graph better represents the incidence of human cancers as a function of age?

Question

Quizplus · Accepted Answer

The incidence of cancers grows exponentially as a function of age in adulthood, although it is thought to reach a plateau or even decline after the age of 80.

The Requirement for Accumulation of Multiple Mutations in Cancer Progression