Indicate true (T) and false (F) statements below regarding the mutational landscape of cancer cells. Your answer would be a four-letter string composed of letters T and F only, e.g. TFFF.
( ) In each cancer, usually there is one driver mutation and a large number of passenger mutations.
( ) It is estimated that about 20% of our genes are cancer-critical.
( ) Cancer-critical genes can encode metabolic enzymes or components of the RNA splicing machinery.
( ) The karyotype is often severely disordered in cancer cells.

Question

Indicate true (T) and false (F) statements below regarding the mutational landscape of cancer cells. Your answer would be a four-letter string composed of letters T and F only, e.g. TFFF.
( )	In each cancer, usually there is one driver mutation and a large number of passenger mutations.
( )	It is estimated that about 20% of our genes are cancer-critical.
( )	Cancer-critical genes can encode metabolic enzymes or components of the RNA splicing machinery.
( )	The karyotype is often severely disordered in cancer cells.

Quizplus · Accepted Answer

The number of driver mutations in most cancers is estimated to be on the order of 10. About 300 genes (less than 2% of our genes) are strongly suspected to be cancer-critical. They encode proteins of various functions. In addition to DNA sequence changes, chromosomal breaks and translocations are common in cancer cells.

Indicate True (T) and False (F) Statements Below Regarding the Mutational