Indicate true (T) and false (F) statements below regarding the complement system. Your answer would be a four-letter string composed of letters T and F only, e.g. TTFT.
( ) The early complement components form the membrane attack complex, whereas the late complement components cleave and activate C3.
( ) The classical pathway of complement activation is triggered by binding of a secreted PRR to mannose-containing glycoproteins or glycolipids on the surface of pathogens.
( ) Some pathogens such as Neisseria gonorrhoeae hide from the complement reaction via sialic acid camouflage.
( ) Once a membrane attack complex is formed, it can attack multiple pathogens before becoming inactivated.

Question

Indicate true (T) and false (F) statements below regarding the complement system. Your answer would be a four-letter string composed of letters T and F only, e.g. TTFT.
( )	The early complement components form the membrane attack complex, whereas the late complement components cleave and activate C3.
( )	The classical pathway of complement activation is triggered by binding of a secreted PRR to mannose-containing glycoproteins or glycolipids on the surface of pathogens.
( )	Some pathogens such as Neisseria gonorrhoeae hide from the complement reaction via sialic acid camouflage.
( )	Once a membrane attack complex is formed, it can attack multiple pathogens before becoming inactivated.

Quizplus · Accepted Answer

Cleavage and activation of the pivotal complement component, C3, is a result of the activation of the early components (by antibodies in the classical pathway, or by lectin binding in the lectin pathway), and in turn activates the late components to form the membrane attack complex. The complex is assembled on a target membrane only and is not reusable as a whole. Most activated complement components are rapidly inactivated.

Indicate True (T) and False (F) Statements Below Regarding the Complement