Indicate whether each of the following descriptions better applies to the clonal anergy (A), clonal deletion (D), receptor editing (E), or clonal suppression (S) mechanism of immunological self-tolerance. Your answer would be a five-letter string composed of letters A, D, E, and S only, e.g. SADSS.
( ) It involves apoptosis of self-reactive cells.
( ) It is mostly limited to B cells.
( ) It involves regulatory T (T??g) cells.
( ) It involves DNA recombination.
( ) It is limited to central tolerance processes.

Question

Indicate whether each of the following descriptions better applies to the clonal anergy (A), clonal deletion (D), receptor editing (E), or clonal suppression (S) mechanism of immunological self-tolerance. Your answer would be a five-letter string composed of letters A, D, E, and S only, e.g. SADSS.
( )	It involves apoptosis of self-reactive cells.
( )	It is mostly limited to B cells.
( )	It involves regulatory T (T??g) cells.
( )	It involves DNA recombination.
( )	It is limited to central tolerance processes.

Quizplus · Accepted Answer

Receptor editing in B cells is a major self-tolerance mechanism that involves V(D)J recombination and occurs exclusively in a central lymphoid organ such as the bone marrow in adults. In clonal deletion, T and B cell clones that encounter self antigens are induced to die by apoptosis. In clonal suppression, T??g cells suppress the activity of self-reactive T and B cells.

Indicate Whether Each of the Following Descriptions Better Applies to the Clonal