COX-2 inhibitors like Vioxx control inflammation without affecting COX-1, but patients taking these drugs are more susceptible to heart attack and stroke. Which of the following is a possible explanation of this side effect?

Question

Quizplus · Accepted Answer

COX-2 plays a role in the proper function of the circulatory system, including maintaining the health of blood vessels and ensuring adequate blood flow. By inhibiting COX-2, COX-2 inhibitors like Vioxx can interfere with this cardiovascular function, leading to an increased risk of heart attack and stroke. This is thought to be the primary explanation for the side effects associated with these drugs. Options A and D are incorrect because COX-2 inhibitors are specifically designed to target only COX-2, not COX-1, and inhibiting both COX-1 and COX-2 is not necessary to prevent inflammation. Option B is also incorrect, as aspirin is not involved in the mechanism of action of COX-2 inhibitors like Vioxx.

COX-2 Inhibitors Like Vioxx Control Inflammation Without Affecting COX-1, but Patients