The main cause of LBM depletion in the HIV-infected person is which of the following?

Question

Quizplus · Accepted Answer

Elevated protein turnover rates are the main cause of LBM (lean body mass) depletion in HIV-infected individuals. This is due to the increased activation of the immune system and cytokine production, which leads to an accelerated breakdown of muscle proteins. Other factors, such as decreased food intake, malabsorption, and deranged metabolism of amino acids may also contribute to LBM depletion, but elevated protein turnover rates are the primary cause. HIV infection leads to increased protein turnover rates, which can cause a depletion of lean body mass (LBM). This is because the body is breaking down muscle tissue to provide amino acids for energy and immune system function, contributing to weight loss and muscle wasting commonly seen in HIV-infected individuals. While lack of protein intake may contribute to LBM depletion, it is not the main cause in HIV. Depleted protein synthesis and deranged metabolism of amino acids may also contribute to LBM depletion, but elevated protein turnover rates are the primary driver of this process.

The Main Cause of LBM Depletion in the HIV-Infected Person