Methotrexate interferes with the metabolism of:

Question

Quizplus · Accepted Answer

Methotrexate acts as an inhibitor for the enzyme dihydrofolate reductase, which interferes with the metabolism of folate. This leads to a reduction in the body's ability to synthesize DNA, RNA, and proteins, which can ultimately lead to cell death. Methotrexate inhibits dihydrofolate reductase, which is necessary for the metabolism of folate. This results in a decrease in folate levels and can lead to side effects such as anemia, mucositis, and GI disturbances. Methotrexate does not interfere with the metabolism of iron, vitamin B₁₂, or calcium directly.

Methotrexate Interferes with the Metabolism Of