In many human colon tumors, the beginning of true malignancy is the result of the

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The loss of part of chromosome 18 is a common genetic alteration observed in human colon tumors, often occurring early in the development of malignancy. This chromosome contains several tumor suppressor genes, the loss of which can lead to uncontrolled cell growth and tumor formation. Inactivation of oncogenes or proto-oncogenes, as well as the arrival of cancerous cells from other parts of the body, may contribute to the progression of colon cancer but are not typically seen as primary drivers of malignancy in this context.

In Many Human Colon Tumors, the Beginning of True Malignancy