The Friedewald equation is used to calculate the concentration of LDL cholesterol in a sample.In cases of suspected lipid disorders,the Friedewald equation should not be used.Which of the following explains why?
A) In lipid disorders, the measure of total cholesterol frequently is less than the measure of HDL, resulting in a negative LDL value.
B) LDL values obtained from the Friedewald equation do not include the concentration of solid, crystalline LDL.
C) The calculation does not take into account interfering concentrations of gaseous CO₂.
D) The Friedewald equation assumes that nearly all the circulating TG is in VLDLs.
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