A set of results that fails the Rule of Three may indicate that

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The Rule of Three is a quality control technique used in laboratory medicine to identify results that are statistically significant and unlikely to have occurred by chance. Failure to meet the Rule of Three may indicate that the result is abnormal or outside of the expected range, which could be indicative of a pathological condition in the patient. Therefore, option A is the best choice. Options B, C, and D are less likely to be the cause of failing the Rule of Three.

A Set of Results That Fails the Rule of Three