The diagnostic label that most closely approximates the lay term "addiction" is substance

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Substance dependence is the diagnostic label used for individuals who exhibit compulsive drug-seeking behavior and use despite the negative consequences. This closely aligns with the lay term "addiction." Substance abuse refers to use that is hazardous or harmful, but may not meet the criteria for dependence. Intoxication refers to the acute effects of a drug, and use simply refers to any consumption of a substance.

The Diagnostic Label That Most Closely Approximates the Lay Term