Genomewide linkage analysis allows researchers studying a disorder to focus on specific areas on specific chromosomes through using large families with the disorder or

Question

Quizplus · Accepted Answer

Genomewide linkage analysis works by comparing the DNA of affected individuals in families to identify regions that are inherited together with the disorder. Therefore, using large samples of affected relative pairs is ideal for this type of analysis. Large groups of non-relatives affected by the disorder or members of large families matched against cohorts from the general population would not provide the necessary familial comparison, and large samples of non-affected relative pairs would not be useful in identifying genetic differences related to the disorder.

Genomewide Linkage Analysis Allows Researchers Studying a Disorder to Focus