The dietary manipulation that is most significantly related to longevity in animal studies is

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Many animal studies have shown that calorie restriction has a significant impact on increasing longevity. This may be due to a variety of biological mechanisms such as reducing oxidative damage, increasing cellular repair, and improving insulin sensitivity. Protein restriction has also been shown to increase lifespan in certain animals, but to a lesser extent compared to calorie restriction. Low fat intake and high carbohydrate intake have not been consistently shown to have a significant impact on longevity in animal studies.

The Dietary Manipulation That Is Most Significantly Related to Longevity