Anticholinesterases ______________.

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Pyridostigmine or neostigmine is used to stimulate neuromuscular receptors which are reduced in number due to destruction by the immune system.They cause diarrhea,which is one of the major problems when treating myasthenia gravis.It can be prevented by use of an anticholinergic/antimuscarinic drug which will selectively block the actions on the muscarinic receptors on the GI tract while not affecting the nicotinic receptors at the skeletal muscle.They constrict bronchi and are contraindicated in asthma.They cause muscular paralysis at overdoses - the nicotinic receptors (only one among autonomic receptors)become insensitive when over-stimulated at high doses and the muscles "escape" and do not contract - paralysis of respiratory muscles is the cause of death.The latter is aggravated by excessive bronchial secretion filling the bronchi with fluid.