At the time of the Revolutionary War, the most powerful Indian tribes who were in contact with the colonists lived between the Appalachian Mountains and the Mississippi River.

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During the time of the Revolutionary War, the most powerful Native American tribes in contact with the colonists, such as the Cherokee, Creek, and Shawnee, inhabited the region between the Appalachian Mountains and the Mississippi River. This area was a significant frontier zone of interaction between Native American tribes and European settlers.

At the Time of the Revolutionary War, the Most Powerful