According to the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), transsexuals, who are experiencing extreme distress as a consequence of their gender variance, would be diagnosed with

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Gender dysphoria is the diagnosis given to individuals who experience significant distress due to a discrepancy between their experienced or expressed gender and the one they were assigned at birth, according to the DSM-5. This diagnosis specifically addresses the psychological distress associated with gender variance, rather than categorizing the variance itself as a disorder.