An extreme example of violating ethical guidelines occurred in the 1940s when U.S. researchers deliberately injected thousands of Guatemalans with sexually transmitted infections (STIs) such as:

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In the 1940s, U.S. researchers conducted unethical experiments in Guatemala by deliberately infecting participants with gonorrhea and syphilis without their consent, violating numerous ethical guidelines.

An Extreme Example of Violating Ethical Guidelines Occurred in the 1940s