Ferdinand and Isabella were the most powerful rulers of the sixteenth century.

Name: Ferdinand and Isabella were the most powerful rulers of the sixteenth century.
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Ferdinand and Isabella were most influential in the late 15th century, specifically during their reigns in Spain from 1479 until their deaths in 1504 (Isabella) and 1516 (Ferdinand). The 16th century is more commonly associated with rulers such as Charles V and Henry VIII.

Ferdinand and Isabella Were the Most Powerful Rulers of the Sixteenth