The E-S complex often shows as a slight depression in the energy profile for the reaction.

Question

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The formation of the enzyme-substrate (E-S) complex often results in a decrease in the system's overall energy, which is represented as a slight depression in the energy profile of the reaction. This is because the E-S complex stabilizes the transition state, lowering the activation energy required for the reaction to proceed.

The E-S Complex Often Shows as a Slight Depression in the Energy