Which of the following types of amino acids in an active site is least likely to be involved in enzyme catalysis?
A) Those with hydrophilic, neutral side-chains.
B) Those with negatively charged side-chains.
C) Those with positively charge side-chains.
D) Those with hydrocarbon side-chains.

Question

Quizplus · Accepted Answer

Amino acids with hydrocarbon side-chains are least likely to be involved in enzyme catalysis because they are hydrophobic and typically do not participate in the chemical reactions or interactions (such as hydrogen bonding, ionic interactions, etc.) that are crucial for catalysis. Catalytic activity often involves the interaction with substrates or the participation in the transition state through mechanisms that require polar or charged side-chains.

Which of the Following Types of Amino Acids in an Active