Telomerase activity may decline with old age and this could explain why cells lose their ability to divide after many replications.

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Telomerase activity, which helps maintain the length of telomeres at the ends of chromosomes, does decline with age in most somatic cells. This decline contributes to telomere shortening, leading to cellular aging and the eventual loss of cell division capability, known as replicative senescence.

Telomerase Activity May Decline with Old Age and This Could