The Δ G values for glycolytic reactions at physiological conditions may be exergonic, even though the Δ G ° ' at "standard" conditions, may be endergonic.

Question

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The ΔG (Gibbs free energy change) of a reaction under physiological conditions can differ from the ΔG°' (standard Gibbs free energy change) because ΔG also depends on the actual concentrations of reactants and products in the cell, which can shift the reaction towards being exergonic (energy-releasing) even if it is endergonic (energy-requiring) under standard conditions.

The Δ G Values for Glycolytic Reactions at Physiological Conditions