Generally speaking, the same mechanisms that activate glycogen phosphorylase will turn off glycogen synthase.

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Glycogen phosphorylase and glycogen synthase are regulated in a reciprocal manner, where the activation of glycogen phosphorylase, which breaks down glycogen, typically coincides with the inhibition of glycogen synthase, which synthesizes glycogen, to ensure that breakdown and synthesis do not occur simultaneously, thus conserving energy.

Generally Speaking, the Same Mechanisms That Activate Glycogen Phosphorylase Will