The first major piece of legislation that stemmed from attitudes condemning drug use was called:

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The Harrison Act, officially known as the Harrison Narcotics Tax Act of 1914, was the first significant piece of federal legislation in the United States that regulated and taxed the production, importation, and distribution of opiates and coca products. This act marked the beginning of the federal government's efforts to regulate and control the use of addictive substances.

The First Major Piece of Legislation That Stemmed from Attitudes