It Can Be Argued That Conflict Between the English Settlers

It can be argued that conflict between the English settlers and local Indians in Virginia became inevitable when

A) the Native Americans realized that England wanted to establish a permanent and constantly expanding colony, not just a trading post.
B) Pocahontas married John Rolfe instead of her longtime suitor John Smith.
C) the House of Burgesses passed a law ordering Native Americans out of the colony.
D) Powhatan led an attack against the English settlers in 1644 that expanded into an all-out war that lasted for decades
E) Spain formed a military alliance with Powhatan and turned against the English.