What Was the Significance of the Ohio Valley During the Eighteenth

What was the significance of the Ohio Valley during the eighteenth century?

A) Large numbers of escaped slaves from the Middle Colonies treated it as a haven and established a lasting settlement there.
B) Both the British and the French respected it as Cherokee territory, creating a precedent for Native American land ownership.
C) The discovery of precious metals elsewhere led to a drastic decline in the population of this area and a decrease of interest in the frontier.
D) Caught in imperial rivalries, it was viewed as a lush and promising location for future white settlement.
E) It was the preferred area of settlement for "crypto-Jews" in North America and attracted many Spaniards.