Sickle cell anemia and cystic fibrosis are examples of a homozygote advantage.

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Sickle cell anemia and cystic fibrosis are genetic disorders caused by mutations in genes. The concept of "homozygote advantage" refers to a situation where being homozygous for a particular trait confers a benefit, but in the context of these diseases, individuals who are homozygous for the mutations suffer from the respective disorders. The advantage often discussed is related to heterozygotes (carriers) in the case of sickle cell anemia, where carriers have a resistance to malaria, but this does not apply to being homozygous for the disease-causing alleles.

Sickle Cell Anemia and Cystic Fibrosis Are Examples of a Homozygote