Colchicine, a chemical extracted from the autumn crocus (C olchicum autumnale ), inhibits the formation of microtubules. Mitotic cells exposed to colchicine will therefore be arrested at ____.

Question

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Colchicine prevents the formation of the mitotic spindle by inhibiting microtubule polymerization. This action arrests cells in metaphase because chromosomes cannot align properly at the metaphase plate without a functional spindle.

Colchicine, a Chemical Extracted from the Autumn Crocus (C Olchicum