How does sickle cell disease cause death?
A) The malformed red blood cells cannot transport oxygen.
B) The malformed red blood cells can block capillaries.
C) The malformed blood cells have a higher affinity for CO2 than for oxygen.
D) The mutant hemoglobin polypeptide cannot bind O2 due to a change in three amino acids.
E) More cells assume the sickle shape as oxygen concentration in the tissues increases.
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