How Does the Cell Overcome Inhibition from Irreversible Inhibitors

How does the cell overcome inhibition from irreversible inhibitors?

A) by binding a second inhibitor, which forces the enzyme's conformation to dislodge the first inhibitor
B) by phosphorylating the enzyme, altering the enzyme's conformation to dislodge the inhibitor
C) by altering the cellular pH, which will decrease the bonding between the enzyme and the inhibitor
D) by degrading the enzyme-inhibitor complex and generating new enzyme
E) by upregulating the expression of other enzymes with similar catalytic functions