Patients with pyruvate dehydrogenase complex deficiency develop neurological symptoms. Patients with this disease fail to make the substrates required for which metabolic process?

Question

Quizplus · Accepted Answer

Pyruvate dehydrogenase complex deficiency leads to an inability to convert pyruvate into acetyl-CoA, which is a crucial substrate for the citric acid cycle. Without acetyl-CoA, the citric acid cycle cannot proceed effectively.

Patients with Pyruvate Dehydrogenase Complex Deficiency Develop Neurological Symptoms