How does sickle cell disease cause death? A) The malformed red blood cells cannot transport oxygen. B) The malformed red blood cells can block capillaries. C) The malformed red blood cells have a higher affinity for CO₂than for oxygen. D) The mutant hemoglobin polypeptide cannot bind O₂due to a change in three amino acids. E) More cells assume the sickle shape as oxygen concentration in the tissues increases.

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The malformed red blood cells can block capillaries, leading to tissue damage and organ failure.

How Does Sickle Cell Disease Cause Death