Neurotransmitters that bind to G-protein-coupled receptors act more rapidly than those binding to ionotropic receptors.

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Neurotransmitters that bind to ionotropic receptors act more rapidly than those binding to G-protein-coupled receptors because ionotropic receptors directly control ion channels, leading to immediate changes in membrane potential, whereas G-protein-coupled receptors initiate a series of intracellular events that take longer to influence cell activity.

Neurotransmitters That Bind to G-Protein-Coupled Receptors Act More Rapidly Than