In laboratory experiments, a single exposure to methamphetamine at high doses or prolonged use at low doses destroyed up to 50 percent of the brain cells that use dopamine.

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Methamphetamine is neurotoxic and can cause significant damage to dopamine neurons in the brain. Studies have shown that high doses or prolonged use can lead to substantial loss of dopamine-producing cells, with some experiments indicating up to 50 percent cell loss.

In Laboratory Experiments, a Single Exposure to Methamphetamine at High