Which of the following four-carbon amides would be the least soluble in water?
A)simple amides
B)monosubstituted amides
C)disubstituted amides
D)all would be equally soluble

Question

Quizplus · Accepted Answer

Disubstituted amides would be the least soluble in water because the substitution of hydrogen atoms with alkyl groups increases the hydrophobic character of the molecule, reducing its ability to form hydrogen bonds with water.

Which of the Following Four-Carbon Amides Would Be the Least