What best describes a major weakness of a laboratory-based study?

Question

What best describes a major weakness of a laboratory-based study? ​

Quizplus · Accepted Answer

Laboratory-based studies are carried out in a controlled environment using animals or in vitro models. Although these studies provide initial insights into the mechanisms and effects of interventions, they are limited in their ability to replicate the complex conditions of the human body in a natural setting. Therefore, the findings of laboratory-based studies may not always be directly applicable to humans, and further clinical trials are needed to confirm the results.

What Best Describes a Major Weakness of a Laboratory-Based Study