Mrs. Z is a 76-year-old female who consults an internal medicine physician because she has been depressed. She also gets chronic migraines. The physician takes a full history from Mrs. Z, which reveals that several medications have been prescribed to her by a variety of specialists. It seems that each specialist neglected to pay attention to the medications that Mrs. Z was prescribed by her other doctors and the potential drug-nutrient interactions. She also takes some daily health supplements.
The physician's notes are as follows:
Current Medication/Supplements       Reason for Prescribing/Taking
St) John's wort ...............................     she read in a magazine that this helps with depression
Slow Fe (iron supplement) ............     for prior anemia
Warfarin .........................................    history of embolic stroke
Omeprazole ...................................     history of peptic ulcer
TUMS ............................................     chronic upset stomach
Amoxicillin ...................................      recent respiratory infection
Doxazosin .....................................    incontinence
Allegra ..........................................      seasonal allergies
Lipitor ...........................................      high cholesterol
Vitamin E ......................................     she heard it was good for heart disease
Typical Daily Diet
Breakfast: eggs, bacon, ½ grapefruit, fresh orange juice
Lunch: hotdogs, sausages, or pepperoni sub, sliced tomatoes, cold tea
Dinner: cooked spinach, chicken breast, mashed potatoes, hot tea
-Considering Mrs. Z is taking Allegra and Lipitor, which element of her diet is a concern for a negative drug-nutrient interaction?

Question

Mrs. Z is a 76-year-old female who consults an internal medicine physician because she has been depressed. She also gets chronic migraines. The physician takes a full history from Mrs. Z, which reveals that several medications have been prescribed to her by a variety of specialists. It seems that each specialist neglected to pay attention to the medications that Mrs. Z was prescribed by her other doctors and the potential drug-nutrient interactions. She also takes some daily health supplements.
The physician's notes are as follows:
Current Medication/Supplements       Reason for Prescribing/Taking
St) John's wort ...............................     she read in a magazine that this helps with depression
Slow Fe (iron supplement) ............     for prior anemia
Warfarin .........................................    history of embolic stroke
Omeprazole ...................................     history of peptic ulcer
TUMS ............................................     chronic upset stomach
Amoxicillin ...................................      recent respiratory infection
Doxazosin .....................................      incontinence
Allegra ..........................................      seasonal allergies
Lipitor ...........................................      high cholesterol
Vitamin E ......................................     she heard it was good for heart disease
Typical Daily Diet
Breakfast: eggs, bacon, ½ grapefruit, fresh orange juice
Lunch: hotdogs, sausages, or pepperoni sub, sliced tomatoes, cold tea
Dinner: cooked spinach, chicken breast, mashed potatoes, hot tea
-Considering Mrs. Z is taking Allegra and Lipitor, which element of her diet is a concern for a negative drug-nutrient interaction?

Quizplus · Accepted Answer

Grapefruit can inhibit the metabolism of certain medications, including Lipitor, leading to increased levels of the medication in the body and potentially harmful side effects. Therefore, Mrs. Z should avoid consuming grapefruit while taking Lipitor.

Mrs Z Is a 76-Year-Old Female Who Consults an Internal