Based on Research Regarding Big Five Personality Traits and Life

Based on research regarding Big Five personality traits and life outcomes, which of the following hypotheses is MOST justifiable?

A) Those high in conscientiousness should be more likely to report experimentation with drugs and alcohol while in college.
B) Those low in neuroticism should be more likely to report experimentation with drugs and alcohol while in college.
C) Those high in openness to experience should be more likely to report experimentation with drugs and alcohol while in college.
D) Those high in conscientiousness and low in openness to experience should be more likely to report experimentation with drugs and alcohol while in college.