An antibody screen on a patient with a prior history of transfusion was negative.The patient had an indication to perform an AHG crossmatch on file.The crossmatch was incompatible with 1 of 5 units selected at AHG phase.What is the next step in the investigation?
A) Perform a prewarm procedure for crossmatching
B) Perform a direct antiglobulin test on the incompatible unit
C) Redraw the patient and begin a new crossmatch
D) Crossmatch a new unit and discard the incompatible unit

Question

Quizplus · Accepted Answer

The most likely reason for the incompatibility is that the blood unit has a positive direct antiglobulin test or the patient has developed an antibody to a low-frequency antibody.If the direct antiglobulin test is negative,testing the patient's serum against a selected cell panel of low-frequency antigen-positive cells should be performed.

An Antibody Screen on a Patient with a Prior History