The first conqueror of the entire plain of Mesopotamia was

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Sargon of Akkad was the first conqueror of the entire plain of Mesopotamia and established the Akkadian Empire in the 24th century BCE. Gilgamesh was a legendary king of Uruk, not a conqueror. Hammurabi was a ruler of Babylon who established a code of laws but did not conquer all of Mesopotamia. Akkad was the city from which Sargon established his empire, not a conqueror. Judea was a region located in the eastern Mediterranean and not relevant to the conquest of Mesopotamia.

The First Conqueror of the Entire Plain of Mesopotamia Was