When a drug produces an unpredictable reaction that is not allergic in nature or due to overdose and resultant toxicity, it is called a(n) ____.

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An idiosyncratic reaction is a rare, unpredictable response that is not related to the normal pharmacological action of a drug and not due to an allergic reaction or overdose. It occurs because of an individual's unique genetic makeup, metabolism, or immune system. Examples include severe liver damage caused by a low dose of acetaminophen in some people, or the development of a serious skin reaction after taking an antibiotic in a few cases.

When a Drug Produces an Unpredictable Reaction That Is Not