The Leahy-Smith America Invents Act of 2011 was the first major change since 1952 involving how:

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The Leahy-Smith America Invents Act of 2011 was the first major change since 1952 involving how the U.S. patent system operates. It changed the U.S. patent system from a first-to-invent to a first-inventor-to-file system, and also implemented post-grant review proceedings for challenging the validity of issued patents.

The Leahy-Smith America Invents Act of 2011 Was the First