In the Selye hypothesis about activation of the stress mechanism,the "alarm signals" act directly on the hypothalamus.

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According to the Selye hypothesis, the initial alarm signals of a stress response (such as a perceived threat or danger) activate the hypothalamus, which sets off a chain reaction involving the release of hormones that ultimately lead to the body's physical response to the stressor.

In the Selye Hypothesis About Activation of the Stress Mechanism,the