A 54-year-old man comes to the physician with recent-onset mild headaches and left leg weakness. The lesions seen on physical examination are shown in the image below. Which of the following inheritance patterns is this patient's disorder most likely to exhibit?

Question

A 54-year-old man comes to the physician with recent-onset mild headaches and left leg weakness.  The lesions seen on physical examination are shown in the image below.  Which of the following inheritance patterns is this patient's disorder most likely to exhibit?

Quizplus · Accepted Answer

11ec160b_3785_f555_9249_f33cd615ab98_MD0001_00 The numerous fleshy, dome-shaped or pedunculated lesions shown in the image are cutaneous neurofibromas, a hallmark of neurofibromatosis type 1 (NF-1). This autosomal dominant condition is caused by a mutation in the NF1 gene, located on chromosome 17. NF-1 has high penetrance (most patients who inherit the gene develop the disease), but the presentation is highly variable. All or none of the following symptoms may be present in an individual who suffers from NF-1: Educational objective: Neurofibromatosis type 1 is a single-gene autosomal-dominant disorder. It occurs due to mutation of the NF1 gene located on chromosome 17. Café-au-lait spots, multiple neurofibromas, and Lisch nodules are the most common symptoms.

A 54-Year-Old Man Comes to the Physician with Recent-Onset Mild