A 32-year-old woman comes to the emergency department due to sudden-onset left-sided facial droop and arm weakness. The patient also has had right leg swelling after a recent road trip. She has no chronic medical conditions, and her only medication is an oral contraceptive. CT scan of the head shows a right middle cerebral artery territory acute infarction. Lower extremity ultrasound examination reveals a right femoral vein thrombus. No obvious cardiac structural abnormalities are detected on an echocardiogram. Agitated normal saline is injected into a peripheral vein to evaluate for abnormal right-to-left shunting. No bubbles are seen in the left side of the heart after several minutes. Which of the following is most appropriate to increase right-sided heart pressure to reveal an obscure intracardiac shunt?
A) Abrupt standing from supine position
B) Amyl nitrate injection
C) Breath-holding after exhalation
D) Sustained hand grip
E) Valsalva maneuver release phase
Correct Answer:
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